Tellurium refining includes refining slag ball milling, leaching, neutralization and precipitation of tellurium, dissolution of tellurium dioxide, reduction, sodium sulfite deselenization, oxidation, solution preparation, tellurium electrowinning, tellurium melting and casting, waste liquid treatment, etc. The process is as follows: after the refining slag is refined by wet ball milling, it is heated and leached with sodium hydroxide solution to allow tellurium to enter the solution; the leachate is neutralized to precipitate tellurium to produce crude tellurium dioxide, which is then dissolved with hydrochloric acid and reduced by introducing sulfur dioxide to obtain crude tellurium; after the crude tellurium is calcined to remove residual selenium, it is electrowon in an alkaline medium to obtain high-purity electrowon tellurium powder.