Diethylene glycol can be used as a gas dehydrating agent, aromatic hydrocarbon extraction solvent, key raw material for polyurethane synthesis, solvent, humectant, etc., and can also serve as an intermediate in the synthesis of other organic compounds, flavors, and pharmaceuticals. This dataset includes main primary and auxiliary materials, energy consumption, and waterborne emissions from the production process; however, infrastructure such as production equipment and facility construction is not included within the system boundary of the dataset. The life cycle inventory was compiled from data obtained from multiple sources. The production process of diethylene glycol involves ethylene production from naphtha cracking, chlorination reaction, saponification reaction, crude distillation, and fine distillation processes.